Season 3 of Prison Break is scheduled to premiere on September 17, 2007; the first seventeen minutes of the season premiere were released on the official website on August 24, 2007.

Series creator Paul Scheuring has commented that the third season will consist of most of the original cast with new additions and that the overall theme will be "redemption". The plot will continue from the second season finale, where most of the main characters have ended up in Panama.

Although the conspiracy storyline has not finished, the third season's plot will be "as different in tone as Season 2 was from Season 1".